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KMID : 0390219990100020231
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Journal of Clinical Otolaryngology, Head and Neck Surgery
1999 Volume.10 No. 2 p.231 ~ p.237
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Morphological Changes of the Olfactory Mucosa in the Chemical Adhesive Inhalation Rat
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정대건/Dae Gun Jung
박해섭/김병국/박소영/박용수/Hae Sup Park/Byung Guk Kim/So Young Park/Young Soo Park
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Abstract
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Background and Objectives : Chemical solvents abuse is a growing public health
problem in the Korea and elsewhere, particularly among young adults and children.
Chemical adhesive is a potent sensory irritant in man and animals due to its high
solubility in nasal mucosa. Inhalation ol chemical adhesives has been to cause hearing
loss and abnormal auditory brainstem responses (ABR) and many neurologic sequelae. In
this study we inverstigated the morphological changes of olfactory mucosa in chemical
adhesive inhaled rat.
Materials and Methods : In 40 healthy Spague-Dawley rat, we examined the of
factory mucosa artier exposure to chemical adhesive.
Results : 1) In experimental groups the olfactory mucosa showed increasing
inflammatory fells in lamina propria and atropic changes, loss of cilia in olfactory
epithelium. 2) These changes are deepened in proportion to exposed days. 3) These
changes are recovered to normal within 3 weeks in case of experimental groups with
the exposed duration is less than 5 days. 4) But these changes are not recovered to
normal within 3 weeks in case of experimental groups which the exposed duration is 7
days.
Conclusion : We concluded that the morphological changes of olfactory mucosa may
be permanent and so the olfactory may be deteriorated when the duration of chemical
adhesive exposure is over 7 days in rats.
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KEYWORD
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